Calbiotech Androstenedione Elisa Kit

Product Description

SUMMARY AND EXPLANATIONAndrostenedione is the primary precursor of testosterone in women. It is synthesized in the adrenal gland.Measurement of Androstenedione may be used as an indicator of androgenic activity in women. The steroid hormoneAndrostenedione is one of the main androgens, besides Testosterone and Dehydroepiandrosterone. In males,androgens are secreted primarily by the Leydig cells of the testes, to some degree also in the adrenal cortex. Infemales, the androgens are secreted mainly in the adrenal glands and in the ovary. Around 10% of the androgens arederived from peripheral conversion, mainly of DHEA. Androstenedione and Testosterone show high diurnal variability.The highest levels are measured in the morning. At the age of puberty serum androstenedione levels rise, aftermenopause they decline again. High androstenedione levels are measured during pregnancy. In women, high levels ofandrostenedione (47-100% above normal) are generally found in hirsutism, mostly in combination with other androgensas testosterone and DHEA-S. Androstenedione overproduction is due to ovarian dysfunction or maybe of adrenal origin.High circulating androstenedione levels are found in women with polycystic ovaries and 21-hydroxylase effect.Significant lower androstenedione levels are found in postmenopausal osteoporosis.